The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma，which permits the interaction of this protein with multiple transcription factors. This protein can interact with，and regulate the activities of cAMP response element binding protein （CREB） and nuclear respiratory factors （NRFs）. It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis，and is a major factor that regulates muscle fiber type determination. This protein may also be involved in controlling blood pressure，regulating cellular cholesterol homoeostasis，and the development of obesity.
應用類型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Jurkat cell lysate can be used as a positive control.
免疫原
Synthetic peptide surrounding amino acid 766 of mouse PGC-1alpha
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的PGC-1alpha蛋白發生免疫反應.
保存建議
提供的PGC-1alpha抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該PGC-1alpha抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
