Telomerase is an RNA-dependant DNA polymerase that catalyzes the addition of telemoric repeat,TTAGGG to chromosome ends. Telomerase is composed of an internal telomerase RNA template (TERC) and the enzyme,telomerase reverse transcriptase (TERT or TP2).?Telomerase expression is usually repressed in postnatal somatic cells resulting in shortening of telomeres. Overexpression of telomerase may be implicated with oncogenesis.
應用類型
Western blot analysis (1-4 ug/ml). However, the optimal conditions should be determined individually. 3T3 cell lysate can be used as a positive control.
免疫原
Synthetic peptide surrounding amino acid 572 of human TP2.
來源宿主
兔
反應性
經檢測驗證,可與人、小鼠、大鼠種屬來源的TP2蛋白發生免疫反應.
保存建議
提供的TP2抗體產品為100 ug 無色溶液,其濃度為0.5 mg/ml,溶解于包含有30%甘油, 0.5% BSA, 0.01%硫柳汞的PBS (pH 7.2)緩沖液中.請將該TP2抗體產品置于-20 ℃冷凍保存,建議分裝使用以避免反復凍融.