AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. It appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5’-AMP rises in response to fuel limitation and/or hypoxia. AMPK alpha1，a member of the Ser/Thr protein kinase family，is a catalytic subunit of AMPK.
應用類型
The antibody can be used for Western blotting （1–4 ug/ml）.
免疫原
Synthetic peptide surroundign amino acid 486 of human AMPK alpha 1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的AMPK?1蛋白發生免疫反應
保存建議
提供的200 ug AMPK?1抗體產品為無色溶液其濃度為0.5 mg/ml溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該AMPK?1抗體產品置于-20 °C冷凍保存，建議分裝使用以避免反復凍融.
