SREBP （Sterol Regulatory Element Binding Protein） 1 and 2 are transcription factors th at regulates cholesterol homeostasis. SREBP proteins are attached to the endoplasmic reticulum and nuclear envelope. SREBP proteins undergo proteolytic cleavage in response to conditions of low cellular sterol. Upon activation of SREBP 1，a soluble NH2 cleavage fragment translocate to the nucleus and activates transcription of enzymes and other proteins required for cholesterol synthesis.
應用類型
The antibody can be used for Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Blocking peptide （Cat.# 3961BP-50） is available separately.
免疫原
Synthetic peptide surrounding amino acid 318 of rat SREBP1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的SREBP1蛋白發生免疫反應
保存建議
提供的100 ug SREBP1抗體產品為無色溶液其濃度為0.5mg/ml溶解于包含有30%甘油， 0.5% BSA， 5 mM EDTA和0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該SREBP1抗體產品置于-20 °C冷凍保存，建議分裝使用以避免反復凍融.
