Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant human Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.
序列
重組人內皮抑素蛋白產品，又稱Collagen alpha-1(XVIII) chain, Endostatin-XV, Related to endostatin, Restin.其對應NCBI基因號為80781，對應Accession號為P39060.
來源宿主
提供的【Endostatin】重組人內皮抑素產品的來源為大腸桿菌重組表達.
溶解建議
重組人內皮抑素產品請按照說明書建議進行溶解操作：Reconstitute with sterile dH?O to a concentration ≥ 1.0 mg/ml, aliquot and store at below –20°C. Avoid freeze-thaw cycles.
