IL-17 was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. The cytokine exhibits a high degree of amino acid identity with HVS13，an open reading frame from a T lymphotropic Herpesvirus saimiri and with murine CTLA8. Supernatant from cells transfected with IL-17 induced IL-16 and IL-18 production and enhanced the surface expression of the intracellular adhesion molecule-1 （ICAM-1） in human fibroblasts. IL-17 is a disulfide-linked homodimer of two 31.0 kDa subunits，each containing 136 amino acid residues.
應用類型
Western blot analysis （0.5-1 ug/ml） and ELISA （2-4 ug/ml）. However， the optimal conditions should be determined individually.
免疫原
E. coli expressed human IL-17
來源宿主
兔
反應性
經檢測驗證，可與人種屬來源的IL-17蛋白發生免疫反應.
保存建議
提供的IL-17抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油， 10 mM EDTA和0.02% thymersal.的PBS （pH 7.2）緩沖液中.請將該IL-17抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
