IL-18 （IFN-gamma-inducing factor，IGIF） is a novel proinflammatory cytokine that augments natural killer （NK） activity in spleen cells. It also has other biological properties such as activation of NF-kB，stimulation of Fas ligand expression，induction of CC and CXC chemokines. IL-18 increases production of competent HIV. IL-18 is related to the IL-1 family. One of the IL-18 receptor chains is the IL-1 receptor-related protein，a member of the IL-1R family. Like IL-1B，IL-18 is first synthesized as a leaderless precursor requiring the IL-1B converting enzyme （ICE） for cleavage into an active molecule. IL-18 may play a role in tissue injury in inflammatory reactions.
應用類型
Western blot analysis （0.5-4 ug/ml）， immunoprecipitation （2-5 ug/ml）， and neutralization （2-5 ug/ml）. However， the optimal conditions should be determined individually.
免疫原
Synthetic peptide of mouse IL-18
來源宿主
兔
反應性
經檢測驗證，可與小鼠種屬來源的IL-18蛋白發生免疫反應.
保存建議
提供的IL-18抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油， 1% BSA， 0.02%硫柳汞的PBS （pH 7.2）緩沖液中.請將該IL-18抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
