The three mammalian isoforms of TGF-beta （TGF-beta1，TGF-beta2，TGF-beta3） signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation，growth，differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis，tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth，and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes ~25kDa TGF-B2 of human， mouse， and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 366 of human TGF-B2
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的TGF-beta2蛋白發生免疫反應.
保存建議
提供的TGF-beta2抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該TGF-beta2抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
