CXCR4 （fusin） is a member in the seven-transmembrane domain G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library. Its ligand is chemokine stroma-derived factor （SDF）. CXCR4 has been shown to be the co-receptor for HIV-1 binding to CD4 through the viral envelope glycoprotein gp120. In other cases，CXCR4 can function as the only receptor for the interaction of HIV-2 with CD4 and host cells. A mouse monoclonal antibody （12G5） to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.
應用類型
Western blot analysis （1 ug/ml）， neutrolization and FACS analysis. However， the optimal conditions should be determined individually.
免疫原
E. coli-expressed rat CXCR4
來源宿主
兔
反應性
經檢測驗證，可與小鼠、大鼠種屬來源的CXCR4蛋白發生免疫反應.
保存建議
提供的CXCR4抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油， 1% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該CXCR4抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
