C3a is an anaphylatoxin generated through activation of the complement C3. C3a is a potent chemoattractant for phagocytes，and it stimulates chemotaxis and other leukocyte functions. C3a binds to eosinophils，basophils，neutrophils，and differentiated U937 cells，that all express receptors for C3a on their cell surface. The C3a receptor has been cloned and shown to be a G protein-coupled receptor with seven putative transmembrane domains. This receptor is characterized for its large extracellular loop between the fourth and fifth transmembrane domains. The loop can be readily detected using the rabbit anti-C3a receptor antibody.
應用類型
The antibody recognizes C3aR expressed in leukocytes and in transfected cells using flow cytometry.
免疫原
E. coli expressed human C3aR （a.a. 161-332）
來源宿主
兔
反應性
經檢測驗證，可與人種屬來源的C3aR蛋白發生免疫反應.
保存建議
提供的C3aR抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02%硫柳汞的PBS緩沖液中.請將該C3aR抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
