IL-21 is a novel cytokine that was recently identified in human and mouse. It has significant homology to IL-2，IL-4，and IL-15. The receptor for IL-21 （IL-21R，also termed NILR for novel interleukin receptor） is a new member of the class I cytokine receptor family. IL-021R forms a complex with the common cytokine receptor g chain and mediates IL-21 signaling. IL-21 and its receptor activates JAK-STAT signaling pathway. IL-21 is expressed in activated T cells，HL-60，and THP-1 cell lines. IL-21 plays an important role in the proliferation and maturation of NK，B and T cell populations.
應用類型
Western blot analysis （1 ug/ml）. However， the optimal conditions should be determined individually. Human A431 cell lysates can be used as a positive control and an approximately 60 kDa band should be detected.
免疫原
Synthetic peptide corresponding to amino acids 20-32 of human IL-21R precursor
