DAP12 （KARAP） is a natural killer （NK） cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs （ITIM），DAP12 contains an immunoreceptor tyrosine-based activation motif （ITAM） in its cytoplasmic domain and is present as a disulphide-bonded homodimer. Crosslinking of DAP 12-KIR complexes （membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain） results in cellular activation.
應用類型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually.
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 94 of mouse DAP-12
來源宿主
兔
反應性
經檢測驗證，可與小鼠、大鼠種屬來源的DAP12蛋白發生免疫反應.
保存建議
提供的DAP12抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該DAP12抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
