VEGF-B，a member of the VEGF family，is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells，regulates angiogenesis and vascular permeability，and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms，formed by alternative splicing，which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif，but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.
應用類型
Western Blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Recombinant human VEGF-B （Cat.# 4642-20） can be used as a positive control.
免疫原
E. coli-expressed recombinant human VEGF-B
來源宿主
兔
反應性
經檢測驗證，可與人種屬來源的VEGF-B蛋白發生免疫反應
保存建議
提供的100 ug VEGF-B抗體產品為無色溶液其濃度為0.5 mg/ml溶解于包含有30%甘油， 0.5% BSA， 5 mM EDTA和0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該VEGF-B抗體產品置于-20 °C冷凍保存，建議分裝使用以避免反復凍融.
