BMPs （bone morphogenetic proteins） belong to the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF-beta superfamily are disulfide-linked dimmers composed of two 12-15 kDa polypeptide chains. As implied by their name，BMPs initiate，promote and regulate bone development，growth，remodeling and repair. Smad1 translocation to the nucleus is observed after the addition of BMP-4 （also designated BMP-2B），suggesting that BMP-4 may play a role in activation of the Smad pathway.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually.
免疫原
Recombinant human BMP-4 expressed from E. coli
來源宿主
兔
反應性
經檢測驗證，可與人種屬來源的BMP-4蛋白發生免疫反應.
保存建議
提供的BMP-4抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該BMP-4抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
