Human IGF-BP5 is a cysteine-rich secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells，fibroblasts or osteoblasts. Studies show that IGF-BP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGF-BP5 overexpressing mice show an increase in neonatal mortality，reduced female fertility，whole body growth inhibition，and retarded muscle development.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Recombinant human IGFBP-5 （Cat.# 4723-25） can be used as a positive control. Other applications have not been determined.
免疫原
E. coli expressed human IGF-BP5
來源宿主
兔
反應性
經檢測驗證，可與人種屬來源的IGF-BP5蛋白發生免疫反應.
保存建議
提供的IGF-BP5抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油和0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該IGF-BP5抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
