Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently，Noggin has been shown to modulate the activities of other BMPs including BMP-2，-7，-13，and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely，transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation，reduced bone formation，and severe osteoporosis.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Recombinant human Noggin （Cat.# 4675-20） can be used as a positive control.
免疫原
E. coli expressed recombinant human Noggin
來源宿主
兔
反應性
經檢測驗證，可與人種屬來源的Noggin蛋白發生免疫反應.
保存建議
提供的Noggin抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該Noggin抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
