【干冰】Anti-NEUROD1 (GOAT) Antibody - 600-101-MN7S-【干冰】Anti-NEUROD1 (GOAT) Antibody - 600-101-MN7S代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: NEUROD1 (Neuronal Differentiation 1) gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. It acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. NEUROD1 associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, it is required for the regulation of amacrine cell fate specification. It is also required for dendrite morphogenesis and maintenance in the cerebellar cortex. NEUROD1 associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Anti-NEUROD1 is useful for researchers interested in Maturity-onset diabetes of the young Type 6, Diabetes mellitus noninsulin-dependent, as well as, developmental biology, DNA-binding transcription factor activity, and protein heterodimerization activity.

免疫原: Anti-NEUROD1 Antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to a N-terminal region of?human Neurogenic differentiation factor 1?conjugated to Keyhole Limpet Hemocyanin (KLH).

保存建議: Store vial at -20° C or below prior to opening. This vial contains a relatively low volume of reagent (25 μL). To minimize loss of volume dilute 1:10 by adding 225 μL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing.

其他: Rockland成立于1962年，是一家老牌抗體原產企業，其位于美國費城郊區的農場保有近20種實驗動物。Rockland公司為生命科學領域提供豐富的、高質量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質、轉錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。