【干冰】Anti-Telomerase catalytic subunit (RABBIT) Antibody - 600-401-252-【干冰】Anti-Telomerase catalytic subunit (RABBIT) Antibody

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背景資料: Telomerase is a reverse transcriptase that adds telomeric repeats (TTAGGG)n to chromosomal ends, compensating for the telomere shortening that occurs with DNA replication.? In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to limited lifespan and senescence.? Reactivation of telomerase activity is associated with human cancer and cell immortalization.? Approximately 85% of human cancers, including breast, prostate, stomach, bladder, colon, and liver cancer, have telomerase activity, whereas most normal somatic cells do not.? The specificity of telomerase to human cancer has led to investigations of telomerase activity and expression as a tumor marker.? For example, the presence of telomerase activity in human urine has been identified as a marker for human bladder carcinoma.? Human telomerase consists of three major subunits:? a catalytic protein subunit called hTERT (for human Telomerase Reverse Transcriptase), a template RNA called hTR, and telomerase-associated protein (TEP-1).?? TERT and hTR are minimally required to reconstitute telomerase activity in vitro.? In human cells, hTR is constitutively expressed. ?TERT transcription is a primary mechanism for regulation of telomerase activity.

應用類型: ELISA,Immunohistochemistry,IF Microscopy,Immunoprecipitation,Western Blot,

免疫原: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminal end of hTERT (accession number AF018167).

保存建議: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產企業，其位于美國費城郊區的農場保有近20種實驗動物。Rockland公司為生命科學領域提供豐富的、高質量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質、轉錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。