The p21-activated kinases (PAKs) are a family of multifunctional serine/threonine kinases involved in a variety of cell functions including stress response, apoptosis and regulation of cell motility and tumor metastasis.? Mammalian PAKs are called 1, 2, 3 or a, g, b respectively.? PAKs are part of a large family of kinases where the catalytic domain of the kinase is related to Ste20 kinase of S. cerevisiae.? Pak activity is regulated by specific binding of GTP-bound Rac and cdc42 GTPases and also by sphingosine and related lipids.? PAK1 activation is induced by a variety of growth factors and G-protein-coupled receptors, Fc receptors, and integrins.? This antibody is specific for the phosphorylated form of PAK 1/2/3.? The selected peptide sequence used to generate the polyclonal antibody is common to all human PAKs.
應用類型
ELISA,Western Blot,
免疫原
Human PAK 1/2/3 phospho peptide corresponding to a region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
來源宿主
Rabbit
反應性
H. sapiens (Human)
保存建議
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
