【干冰】Anti-STAT6 pY641 (RABBIT) Antibody - 600-401-C67-【干冰】Anti-STAT6 pY641 (RABBIT) Antibody

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背景資料: Anti-STAT6 phospho Y641 Antibody is ideal to study STAT6. STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT6 is involved in interleukin-4 signaling. It interacts with NCOA1 via its C-terminal LXXLL motif. Further it induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Following stimulation by IL-4 and IL-3, Stat6 is activated via phosphorylation at Tyr641 and translocates to the nucleus where it regulates cytokine-induced gene expression. STAT6 research areas include Immunology, Signal Transduction and Chromatin & Nuclear Signaling.

免疫原: STAT6 phospho Y641 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a phosphorylated synthetic peptide corresponding to residues surrounding Tyrosine 641 of human STAT6 protein.

保存建議: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產企業，其位于美國費城郊區的農場保有近20種實驗動物。Rockland公司為生命科學領域提供豐富的、高質量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質、轉錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。