Tryptophan Hydroxylase pS260 antibody detects Tryptophan Hydroxylase, which catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II). CaM K II phosphorylates Ser260 which lies within the regulatory domain of TPH. Anti-THPpS260 Antibody is ideal for investigators involved in Cell Signaling, and Neuroscience research.
應用類型
Western Blot,
免疫原
Anti-Tryptophan Hydroxylase pS260 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser260 of Tryptophan Hydroxylase.
來源宿主
Rabbit
反應性
H. sapiens (Human); Rattus (Rat)
保存建議
Store vial at -20° C prior to opening.? This product is stable at 4° C as an undiluted liquid.? For extended storage, aliquot contents and freeze at -20° C or below.? Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
