- 中文名稱
【干冰】Anti-TBK1 (RABBIT) Antibody - 600-401-MK6S
- 英文名字
- 【干冰】Anti-TBK1 (RABBIT) Antibody - 600-401-MK6S
- 供應商
- Rockland
- 產品貨號
- 600-401-MK6S
- 產品報價
- ￥詢價/25uL
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- TBK1 (TANK Binding Kinase 1) is a serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, it associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, it functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB, or RELA to translocate NF-Kappa-B to the nucleus. It restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on Ser-177, thus enhancing LC3 binding affinity and antibacterial autophagy. TKB1 phosphorylates the SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation. And it phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. And it phosphorylates Borna disease virus (BDV) P protein. Anti-TBK1 Antibody is useful for researchers interested in Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 4, acute Infection-Induced 8 Encephalopathy, Toll-like Receptor Signaling Pathway, TNFR1 Pathway, nucleic acid binding, and protein kinase activity.
- 應用類型
- ELISA,Immunohistochemistry,IF Microscopy,Western Blot,
- 免疫原
- Anti-TBK1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a C-terminal portion of human TBK1 conjugated to Keyhole Limpet Hemocyanin (KLH).
- 來源宿主
- Rabbit
- 反應性
- H. sapiens (Human); Mus musculus (Mouse)
- 保存建議
- Store vial at -20° C or below prior to opening. This vial contains a relatively low volume of reagent (25 μL). To minimize loss of volume dilute 1:10 by adding 225 μL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing.
- 其他
- Rockland成立于1962年，是一家老牌抗體原產企業，其位于美國費城郊區的農場保有近20種實驗動物。Rockland公司為生命科學領域提供豐富的、高質量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質、轉錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
-
