2-Arachidonyl glycerol ether （2-AG ether） has been isolated from porcine brain and its structure determined by mass spec analysis. 2-AG ether has also been synthesized as an analog of the endogenous cannabinoid （CB）， 2-AG， for structure activity testing. 2-AG ether is a selective central cannabinoid （CB1） receptor agonist exhibiting Ki values of 21.2 nM and >3 uM at the CB1 and peripheral cannabinoid （CB2） receptors， respectively， and displays the typical tetrad of CB activities in mice. It is much more chemically stable than 2-AG， with an endogenous half-life of hours rather than minutes. However， it is at least 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses. 2-AG ether elicits modest reductions in IOP in rabbits when administered at doses exceeding 50 ug per eye. 2-AG ether increases aqueous humor outflow via the CB1 receptor in the trabecular meshwork.
產品描述
A selective CB1 receptor agonist exhibiting Ki values of 21.2 nM and >3 uM at the CB1 and CB2 receptors， respectively； more chemically stable than 2-AG， with an endogenous half-life of hours rather than minutes but 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses； elicits modest reductions in IOP in rabbits when administered at doses exceeding 50 ug per eye and increases aqueous humor outflow via the CB1 receptor in the trabecular meshwork
