Hexokinase is the first enzyme in the glycolytic pathway, catalyzing the transfer of a phosphoryl group from ATP to glucose to form glucose-6-phosphate and ADP. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV This enzyme is found in most cells, but there is tissue specificity for the particular type of hexokinase. Hexokinase 2 is found in the skeletal muscle and includes hydrophobic N-terminal sequence capable of targeting the hexokinase to mitochondria. It also constitutes the principal regulated isoform in many other cell types and is increased in many cancers. Although found in NIDDM patients, genetic variations of HK 2 do not contribute to the disease.
序列
重組人己糖激酶 2 蛋白產品，又稱Hexokinase type II, Muscle form hexokinase, HK2.其對應NCBI基因號為3099，對應Accession號為P52789.
來源宿主
提供的【Hexokinase 2 】重組人己糖激酶 2 產品的來源為大腸桿菌重組表達.
溶解建議
重組人己糖激酶 2 產品為液體即用型，其溶液組成為：1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
