Cyclophilin B is a cyclosporine-binding protein. It is both secreted and retained in the ER. When secreted, Cyclophilin B mediates chemotaxis and T cell adhesion to fibronectin. This is likely due to its prolyl?cis/trans?isomerase activity. Intracellularly, Cyclophilin B appears to serve as a molecular chaperone for molecules destined for secretion. It does so via stabilization, and facilitating the activity of additional chaperones. It also bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.
序列
重組人親環蛋白 B 蛋白產品，又稱PPIB, Peptidyl prolyl isomerase B, CYPB; SCYLP; CYP-S1.其對應NCBI基因號為5479，對應Accession號為P23284.
來源宿主
提供的【Cyclophilin B 】重組人親環蛋白 B 產品的來源為大腸桿菌重組表達.
溶解建議
重組人親環蛋白 B 產品為液體即用型，其溶液組成為：1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20 mM NaCl, 0.5 mM DTT, 10% glycerol.
保存建議
在您收到艾美捷發出的【Cyclophilin B 】重組人親環蛋白 B 產品后，建議將其置于-80°C保存.
