FKBP3 is part of a family of immunosuppressant receptors which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 accelerates the folding of proteins. FKBP3 is part of the immunophilin protein family, which participates in immunoregulation and fundamental cellular processes concerning protein folding and trafficking. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a greater affinity for rapamycin than for FK506 and therefore is a significant protein for immunosuppression by rapamycin.
序列
重組人FKBP3蛋白產品，又稱FK506 binding protein 3, FKBP25, PPIase FKBP3, Rotamase.其對應NCBI基因號為2287，對應Accession號為Q00688.
來源宿主
提供的【FKBP3】重組人FKBP3產品的來源為大腸桿菌重組表達.
溶解建議
重組人FKBP3產品為液體即用型，其溶液組成為：1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.
