FKBP4 is part of the immunophilin protein family, which takes part in immunoregulation and necessary cellular processes concerning protein folding and trafficking. It is a cis-trans prolyl isomerase that connects to the immunosuppressants FK506 and rapamycin. FKBP4 has high structural and functional similarity to FKBP1A, although, FKBP4 does not have immunosuppressant activity when complexed with FK506. FKBP4 interacts with interferon regulatory factor-4 and is involved in immunoregulatory gene expression in B and T lymphocytes. FKBP4 is known to connect with phytanoyl-CoA alpha-hydroxylase. FKBP4 associates with HSP90 & HSP70 thus takes part in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. FKBP4 highly associates with adeno-associated virus type 2 vectors (AAV) resulting in a considerable increase in AAV-mediated transgene expression in human cell lines. FKBP4 is involved in the optimal use of AAV vectors in human gene therapy.
序列
重組人FKBP4蛋白產品，又稱FK506 binding protein 6, FKBP52, FKBP59, HBI, Hsp56, p52, PPIase.其對應NCBI基因號為2288，對應Accession號為Q02790?.
來源宿主
提供的【FKBP4】重組人FKBP4產品的來源為大腸桿菌重組表達.
溶解建議
重組人FKBP4產品為液體即用型，其溶液組成為：1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
