DUSP3 belongs to the dual specificity protein phosphatase subfamily which inactivates their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSP3 negatively regulate members of the mitogen-activated protein kinase superfamily that are related to cellular proliferation and differentiation. DUSP3 is expressed in both breast and ovarian tissues and displays activity both for tyrosine-protein phosphate and serine-protein phosphate, but exhibits a strong preference toward phosphotyrosines, specifically dephosphorylates and inactivates ERK1 and ERK2.
序列
重組人DUSP3蛋白產品，又稱Dual specificity protein phosphatase 3, VHR.其對應NCBI基因號為1845，對應Accession號為P51452.
來源宿主
提供的【DUSP3】重組人DUSP3產品的來源為大腸桿菌重組表達.
溶解建議
重組人DUSP3產品為液體即用型，其溶液組成為：1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2 mM DTT and 0.15 M NaCl.
