LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA is localized primarily in muscle tissue and is part of the lactate dehydrogenase family. Mutations in LDHA have been linked to exertional myoglobinuria. LDH1 is decreased in essential thrombocythemia. LDHA is induced through a non-genomic pathway of estrogen action. Reduction in LDH-A activity results in stimulation of mitochondrial respiration and decrease of mitochondrial membrane potential.
序列
重組人LDHA蛋白產品，又稱L-lactate dehydrogenase A chain, GSD11, LDH1, LDHM, PIG19.其對應NCBI基因號為3939，對應Accession號為P00338.
來源宿主
提供的【LDHA】重組人LDHA產品的來源為大腸桿菌重組表達.
溶解建議
重組人LDHA產品為液體即用型，其溶液組成為：0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 20% glycerol.
