CD13，or aminopeptidase N，is a type II transmembrane glycoprotein that is expressed on most cells of Myeloid origin，including monocytes，basophils，eosinophils，neutrophils and Myeloid leukemias. CD13 is also found on certain epithelial cells，fibroblasts and osteoclasts. CD13 acts as a zinc-binding metalloprotease that plays a role in digestion and may function in the inactivation of some regulatory peptides such as enkephalins. CD13 may play a role in the invasion of cancer cells by enhancing their invasive capacity and metastatic behavior. The activity of CD13 can be inactivated using specific inhibitors that evoke apoptosis of CD13-positive cancer cells. Basic fibroblast growth factor （bFGF） expression upregulates CD13 expression in human melanoma cells by activating both the Myeloid and the epithelial CD13 promoter.
應用類型
WB: 1:100 – 1:250
免疫原
This ANPEP/CD13 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from human ANPEP/CD13.
