RARA is a receptor for retinoic acid，a vitamin A metabolite，which directly regulates gene expression in target cells by binding to specific DNA response elements. In the absence of its ligand，this receptor represses transcription through the recruitment of specific corepressors and of HDAC’s，whereas binding of retinoic acid causes the recruitment of coactivators and HAT’s. Translocations involving the RARA gene，often leading to a RARA/PML fusion protein，are a major cause of acute promyelocytic leukemia.
應用類型
ChIP: 4 ug/ChIP， WB: 1:750， ELISA: 1:50.
免疫原
Human RARA （Retinoic Acid Receptor alpha） using two KLH-conjugated synthetic peptides containing sequences from the C-terminal region of the protein.
