Set9 is a histone methyltransferase which specifically methylates lysine 4 of histone H3 being a specific tag for epigenetic transcriptional activation. Further，methylation of histone H3K4 by Set9 precludes deacetylation of H3 by the NuRD complex and impairs Suv39h1-mediated methylation of H3K9. Set9 also methylates the tumor suppressor p53 at lysine 372，thereby enhancing its stability. It contains a SET domain but lacks the pre- and post-SET domains）.
應用類型
Western Blot: 1:1000
免疫原
Polyclonal antibody raised in rabbit against human Set9 （SET domain containing （lysine methyltransferase） 9）， using a recombinant protein.
