TREM2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
序列
重組人TREM2蛋白產品，又稱Triggering receptor expressed on myeloid cells 2, Trem2a, Trem2b, Trem2c.其對應NCBI基因號為54209，對應Accession號為Q9NZC2.
來源宿主
提供的【TREM2】重組人TREM2產品的來源為大腸桿菌重組表達.
溶解建議
重組人TREM2產品為液體即用型，其溶液組成為：0.25 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 10% glycerol.
