中文名稱

【BRD2】重組人BRD2 bromodomain結構域（1-455 aa）（帶His標簽）（100 ug）

英文名字

BRD2 bromodomain (1-455 aa) (His-Tag), human recombinant

供應商

Biovision

產品貨號

7406-100

產品報價

￥已停產

產品說明書

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購買方式

銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868.

產品新聞

背景資料

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.

序列

重組人BRD2 bromodomain結構域(1-455 aa) (帶His標簽)蛋白產品，又稱RING3, RNF3, Bromodomain containing 4, D6S113E, FSH, FSRG1, NAT, RING3, RNF3.其對應NCBI基因號為6046，對應Accession號為P25440.

來源宿主

提供的【BRD2】重組人BRD2 bromodomain結構域(1-455 aa) (帶His標簽)產品的來源為大腸桿菌重組表達.

溶解建議

重組人BRD2 bromodomain結構域(1-455 aa) (帶His標簽)產品為液體即用型，其溶液組成為：1 mg/ml in Phosphate buffer saline (pH 7.4) containing 10% glycerol and 1 mM DTT.

保存建議

在您收到艾美捷發出的【BRD2】重組人BRD2 bromodomain結構域(1-455 aa) (帶His標簽)產品后，建議將其置于-80°C保存.

其他

BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的Leader，BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供優質、新的細胞生物學研究工具而不斷擴大產品及服務質量.

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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