【PD-1 / PDCD1】重組小鼠PD-1 / PDCD1，帶C-Fc標簽蛋白（50 ug）-Human CellExp PD-1 /PDCD1, C-Fc Tag, mouse recombinant代理/參數/廠家-重組蛋白-艾美捷科技有限公司

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背景資料: Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. This protein is suitable for use in protein studies such as protein structure analysis and protein-protein interactions. It can also be used as an immunogen, as a protein standard, or in cell biology research applications.

序列: 重組小鼠PD-1 /PDCD1,帶C-Fc標簽蛋白又稱PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l.其對應NCBI基因號為18566，對應Accession號為Q02242.

溶解建議: 重組小鼠PD-1 /PDCD1,帶C-Fc標簽蛋白產品為凍干形式，打開產品儲存管之前請離心.將其重新溶解于無菌的PBS緩沖液（pH 7.4）中到終濃度為50 ug/ml，避免渦旋溶解.

保存建議: 在您收到艾美捷發出的【PD-1/PDCD1】重組小鼠PD-1 /PDCD1,帶C-Fc標簽蛋白產品后，建議將其置于-20°C保存，產品有效期為收到產品后12個月.

其他: BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的Leader，BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供優質、新的細胞生物學研究工具而不斷擴大產品及服務質量.