【IGF1】人源細胞表達重組人胰島素樣生長因子1-Human CellExp? IGF-1, human recombinant代理/參數/廠家-重組蛋白-艾美捷科技有限公司

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中文名稱: 【IGF1】人源細胞表達重組人胰島素樣生長因子1

英文名字: Human CellExp? IGF-1, human recombinant

供應商: Biovision

產品貨號: 7507-20

產品報價: ￥已停產

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背景資料: Insulin-like growth factor 1 (IGF-1) also known as somatomedin C, IGF1A, IGFI, sulfation factor, and is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. IGF-1 binds to at least two cell surface receptors: the Insulin-like growth factor 1 receptor, abbreviated as "IGF1R", and the insulin receptor. The IGF-1 receptor seems to be the "physiologic" receptor - it binds IGF-1 at significantly higher affinity than the IGF-1 that is bound to the insulin receptor. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. Its primary action is mediated by binding to its specific receptor IGF1R, present on many cell types in many tissues. Binding to the IGF1R, a receptor tyrosine kinase, initiates intracellular signaling; IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death. Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 Binding Proteins (IGFBPs), of which there are six (IGFBP1-6).

序列: 人源細胞表達重組人胰島素樣生長因子1又稱IGF-I, IGF1A, somatomedin C, MGF .其對應NCBI基因號為3479，對應Accession號為P05019.

來源宿主: 提供的【IGF1】人源細胞表達重組人胰島素樣生長因子1蛋白產品來源為人胚腎HEK 293細胞中重組表達.

溶解建議: 提供的人源細胞表達重組人胰島素樣生長因子1產品為固體凍干粉形式.開蓋前，請先離心.溶解于PBS緩沖液中, pH 7.4. 請勿渦旋！

保存建議: 艾美捷推薦冰袋運輸【IGF1】人源細胞表達重組人胰島素樣生長因子1產品.我們建議您收到該產品后將其置于-20°C保存.產品有效期為收到產品后12個月.

其他: BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的Leader，BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供優質、新的細胞生物學研究工具而不斷擴大產品及服務質量.