Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
序列
重組小鼠Notch-1蛋白蛋白產品，又稱Neurogenic Locus Notch Homolog Protein 1; Notch A; mT14; p300.其對應NCBI基因號為18128，對應Accession號為Q01705.
來源宿主
提供的【Notch 1】重組小鼠Notch-1蛋白產品的來源為中國倉鼠卵巢CHO細胞重組表達.
溶解建議
重組小鼠Notch-1蛋白產品請按照說明書建議進行溶解操作：Reconstitute with sterile water to 1 mg/ml.
