SMN2】重組人SMN Tudor Domain（1472-1613 aa）（帶GST標簽）（20 ug）-SMN Tudor Domain (1472-1613 aa) (GST-tagged), Human recombinant代理/參數/廠家-重組蛋白-艾美捷科技有限公司

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背景資料: Tudor domains are small protein structural motifs of ~50 amino acids related to the “Royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification and chromatin remodeling. The tudor domains recognize symmetric methylated arginine or methylated lysine residues. The Survival of Motor Neurons (SMN) protein participates in RNA splicing. The Tudor domain of SMN recognizes and binds methylated Sm proteins, which bind small nuclear RNA. SMN is encoded in humans by two separate genes, SMN1 and SMN2, which differ by one base in exon 7. In motor neuron cells, approximately 90% of the SMN2 transcripts are spliced to exclude exon 7. The SMN2 transcripts without exon 7 are less stable than SMN1 transcripts. Consequently, defects in human SMN1 result in the death of motor neuron cells and spinal muscular atrophy, which is the leading genetic cause of infantile death. This protein product contains the tudor domain region of SMN. The sequence of this region is identical in both the SMN1 and the SMN2 genes.

序列: 重組人SMN Tudor Domain (1472-1613 aa) (帶GST標簽)蛋白產品，又稱Gemin-1; Component of Gems 1; Survival Motor Neuron Protein.其對應NCBI基因號為6606 6607，對應Accession號為Q16637.

來源宿主: 提供的【SMN1 SMN2】重組人SMN Tudor Domain (1472-1613 aa) (帶GST標簽)產品的來源為大腸桿菌重組表達.

溶解建議: 重組人SMN Tudor Domain (1472-1613 aa) (帶GST標簽)產品為液體即用型，其溶液組成為：50 mM Tris-HCl, 150 mM sodium chloride, pH 8.0, containing 20% glycerol.

保存建議: 在您收到艾美捷發出的【SMN1 SMN2】重組人SMN Tudor Domain (1472-1613 aa) (帶GST標簽)產品后，建議將其置于-80°C保存.

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