中文名稱

【PKCmu】PKCmu蛋白，有活性的（5 ug）

英文名字

PKCmu, Active

供應商

Biovision

產品貨號

7745-5

產品報價

￥已停產

產品說明書

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購買方式

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產品新聞

背景資料

Protein kinase Cmu (PKCmu) is a novel member of the protein kinase C (PKC) family that differs from the other isoenzymes in structural and enzymatic properties. It is characterized by the presence of a pleckstrin homology (PH) domain and an amino-terminal hydrophobic region and has substrate specificity distinct from other PKC isoforms. PKCmu is a ubiquitous PKC isotype with the highest expression in the thymus, lung and peripheral blood mononuclear cells (1). PKCmu forms a complex in vivo with a phosphatidylinositol 4-kinase and a phosphatidylinositol-4-phosphate 5-kinase. A region of PKCmu between the amino-terminal transmembrane domain and the pleckstrin homology domain is shown to be involved in the association with the lipid kinases (2). PKCmu was also shown to associate with the B cell receptor (BCR) complex and its activity is up-regulated after cross-linking the BCR and CD19 on B cells (3). PKC mu co-precipitates with Syk and phospholipase C-γ 1/2 (PLC γ 1/2) and in vitro phosphorylation of fusion proteins showed that both Syk and PLC γ 1 are potential substrates of PKC mu in vivo. In addition, specific interaction of PKCmu and 14-3-3tau can be shown in the T cell line Jurkat by immunocoprecipitiation and by pulldown assays (4). 14-3-3tau is not a substrate of PKCmu and strongly down-regulates PKCmu kinase activity in vitro. In response to various stimuli, PKC mu activates the mitogen-activated protein kinase (p42/ERK1 MAPK cascade) but does not affect the related c-jun N-terminal kinase or p38 MAPK (5).

序列

PKCmu蛋白,有活性的蛋白產品，又稱PKC, Protein kinase C mu.其對應NCBI基因號為5567，NCBI基因別稱為PRKACB源，對應Accession號為NM_002731.該蛋白產品又稱Active PKCmu, PKCmu, PKC, human PKAmu, active kinase, active kinases, recombinant PKCmu, recombinant PKC, kinase activity assay, protein kinase等.

來源宿主

提供的【PKCmu】PKCmu蛋白,有活性的產品的來源為Sf9昆蟲細胞-桿狀病毒中重組表達.

溶解建議

提供的PKCmu蛋白,有活性的 產品為液態形式溶解于儲存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中.

保存建議

在您收到艾美捷發出的【PKCmu】PKCmu蛋白,有活性的產品后，建議將其置于-80°C保存.

其他

BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的Leader，BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供優質、新的細胞生物學研究工具而不斷擴大產品及服務質量.

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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