DuSP10 (Dual specificity protein phosphatase 10) belongs to the protein-tyrosine phosphatase family. Dual specificity protein phosphatases (DuSPs) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. DuSP10 has been shown to interact with MAPK14 and MAPK8. When expressed in mammalian cells, DuSP10 blocks the enzymatic activation of MAP kinases with the selectivity p38 approximately JNK/SAPK >> ERK. Recombinant human DuSP10 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
序列
重組人DUSP10蛋白產品，又稱Dual specificity protein phosphatase 10, MKP5.其對應NCBI基因號為11221，對應Accession號為Q9Y6W6?.
來源宿主
提供的【DUSP10】重組人DUSP10產品的來源為大腸桿菌重組表達.
溶解建議
重組人DUSP10產品為液體即用型，其溶液組成為：0.25 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 50% glycerol, 0.2 M NaCl and 2 mM DTT
