【PDCD1】人源細胞表達重組人生物素標記細胞程序性死亡蛋白1（His Tag＆Fc Tag）-Human CellExp? Biotinylated PD-1 / PDCD1, His Tag & Fc Tag, human recombinant代理/參數/廠家-重組蛋白-艾美捷科技有限公司

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英文名字: Human CellExp? Biotinylated PD-1 / PDCD1, His Tag & Fc Tag, human recombinant

背景資料: Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway.
The Biotinylated Human PD-1 / PDCD1 Protein, His Tag & Fc Tag was produced using proprietary single-point enzymatic biotinlabeling technology at C-terminus to retain its native conformational structure and, therefore, bioactivity, and has been used successfully for high sensitivity and low variability assays, such as ELISA, western blotting, inhibition assay, pull-down, SPR, FACS, and affinity purification, together with anti-biotin antibody, streptavidin or avidin-conjugated probes.

序列: 人源細胞表達重組人生物素標記細胞程序性死亡蛋白1( His Tag & Fc Tag)又稱PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l.其對應NCBI基因號為5133，對應Accession號為Q15116.

來源宿主: 提供的【PDCD1】人源細胞表達重組人生物素標記細胞程序性死亡蛋白1( His Tag & Fc Tag)蛋白產品來源為人胚腎HEK 293細胞中重組表達.

溶解建議: 提供的人源細胞表達重組人生物素標記細胞程序性死亡蛋白1( His Tag & Fc Tag)產品為固體凍干粉形式.開蓋前，請先離心.溶解于無菌PBS溶液（pH 7.4），濃度為50 ug/ml. 請勿渦旋！2-8°C可保存1 month . 長期保存, 推薦保存于-20℃..

保存建議: 艾美捷推薦冰袋運輸【PDCD1】人源細胞表達重組人生物素標記細胞程序性死亡蛋白1( His Tag & Fc Tag)產品.我們建議您收到該產品后將其置于-20°C保存.產品有效期為收到產品后12個月.

其他: BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的Leader，BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供優質、新的細胞生物學研究工具而不斷擴大產品及服務質量.