The endocannabinoids （ethanolamides and 2-glyceryl esters of unsaturated fatty acids， mainly arachidonate） are ligands for the central cannabinoid （CB1） and peripheral cannabinoid （CB2） G-protein coupled receptors. HU-308 is a potent， selective agonist for the peripheral CB2 receptor. The Ki for CB1 is >10 uM， while the Ki for CB2 is approximately 20 nM. When administered to whole animals， HU-308 elicits hypotensive， analgesic， and anti-inflammatory activity， but none of the behavioral tetrad of psychomotor responses characteristic of the phenolic components of hemp， such as .DELTA.9-THC.
產品描述
HU-308 is a potent， selective agonist for the CB2 receptor. The Ki value for CB1 is >10 uM， while the Ki value for CB2 is approximately 20 nM. When administered to whole animals， A potent， selective agonist for the CB2 receptor （Ki = ~20 nM compared to that of CB1 Ki = >10 uM）； elicits hypotensive， analgesic， and anti-inflammatory activity， but none of the behavioral tetrad of psychomotor responses characteristic of the phenolic components of hemp， such as Δ9-THC when administered to whole animals
