AZD-7762（25毫克）產品是AZD7762 is a potent, ATP-competitive, reversible, checkpoint kinase inhibitor with IC??s at 5 nM and <10 nM for Chk1 and Chk2, respectively. AZD 7762 abrogates DNA damage-induced S and G2?checkpoints with an EC???value of 10 nM and potentiates the efficacy of DNA-damage repair prohibitive agents, gemcitabine and topotecan, both?in vitro?and in various tumor xenografts by modulating downstream checkpoint pathway proteins.
