LH-846(10毫克)產品是LH-846 is a potent and selective inhibitor of casein kinase (CK) 1δ?(IC?? values are 290 nM, 1.3?uM and 2.5?uM for CK1δ,?ε?andα); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. LH846 increases circadian period by 10 hours in human U2OS cells.