利戈塞替尼(25 mg)產品是Rigosertib is a potent, specific PLK1 (Polo -Like Kinase 1) inhibitor (IC?? = 9 nM). Rigosertib strongly inhibits the proliferation of cancer cell lines, with observed IC???values in the nanomolar range for both HeLa (115?nM) and C33A (45?nM) cells. In contrast, Rigosertib has a minimal effect on normal cell lines, BJ and Ect1/E6E7 (IC???>?0.1?mM).