BMS-83??3923(5毫克)產品是BMS-833923 is a potent inhibitor of Smo (Smoothened) with potential antineoplastic activity.?It blocks binding of BODIPY cyclopamine (IC???= 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC??s = 6-35 nM). BMS-833923 inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.