The protein encoded by this gene is a member of the
TNF-receptor superfamily. This receptor has been found to be
essential in mediating a broad variety of immune and inflammatory
responses including T cell-dependent immunoglobulin class
switching, memory B cell development, and germinal center
formation. AT-hook transcription factor AKNA is reported to
coordinately regulate the expression of this receptor and its
ligand, which may be important for homotypic cell interactions.
Adaptor protein TNFR2 interacts with this receptor and serves as a
mediator of the signal transduction. The interaction of this
receptor and its ligand is found to be necessary for
amyloid-beta-induced microglial activation, and thus is thought to
be an early event in Alzheimer disease pathogenesis. Two
alternatively spliced transcript variants of this gene encoding
distinct isoforms have been reported.
