- 中文名稱
TFE3抗體(N端)
- 英文名字
- TFE3 Antibody (N-term)
- 供應商
- Abgent
- 產品貨號
- A-AP18316A
- 產品報價
- ￥2600/400 ul
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- The microphthalmia transcription factor/transcription
factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper
(bHLH-Zip) transcription factors includes four family members:
MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene
activates transcription through binding to the muE3 motif of the
immunoglobulin heavy-chain enhancer. The TFEC protein forms
heterodimers with the TEF3 protein and inhibits TFE3-dependent
transcription activation. The TEF3 protein interacts with
transcription regulators such as E2F3, SMAD3, and LEF-1, and is
involved in TGF-beta-induced transcription, playing important roles
in cell growth, proliferation, and osteoclast and macrophage
differentiation. The TFE3 protein also activates hepatic IRS-2
gene, and induces hexokinase II (HK2) and insulin-induced gene 1
(INSIG1); it participates in insulin signaling and could be a
therapeutic target for diabetes. This gene is also involved in
chromosomal translocations, resulting in different fusion gene
products in papillary renal cell carcinomas and alveolar soft part
sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO
(p54nrb)-TFE3 and ASPL-TFE3.
- 應用類型
- WB
- 免疫原
- P19532
- 來源宿主
- 反應性
- 保存建議
- 其他
- ABGENT
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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