This gene is regulated as part of the p53 tumor suppressor
pathway and encodes a protein with sequence similarity to the
bisphosphate domain of the glycolytic enzyme that degrades
fructose-2,6-bisphosphate. The protein functions by blocking
glycolysis and directing the pathway into the pentose phosphate
shunt. Expression of this protein also protects cells from DNA
damaging reactive oxygen species and provides some protection from
DNA damage-induced apoptosis. The 12p13.32 region that includes
this gene is paralogous to the 11q13.3 region. [provided by
RefSeq].
