- 中文名稱
F13B抗體(N端)
- 英文名字
- F13B Antibody (N-term)
- 供應商
- Abgent
- 產品貨號
- A-AP20162a
- 產品報價
- ￥2310/400 ul
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- This gene encodes coagulation factor XIII B subunit.
Coagulation factor XIII is the last zymogen to become activated in
the blood coagulation cascade. Plasma factor XIII is a
heterotetramer composed of 2 A subunits and 2 B subunits. The A
subunits have catalytic function, and the B subunits do not have
enzymatic activity and may serve as a plasma carrier molecules.
Platelet factor XIII is comprised only of 2 A subunits, which are
identical to those of plasma origin. Upon activation by the
cleavage of the activation peptide by thrombin and in the presence
of calcium ion, the plasma factor XIII dissociates its B subunits
and yields the same active enzyme, factor XIIIa, as platelet factor
XIII. This enzyme acts as a transglutaminase to catalyze the
formation of gamma-glutamyl-epsilon-lysine crosslinking between
fibrin molecules, thus stabilizing the fibrin clot. Factor XIII
deficiency is classified into two categories: type I deficiency,
characterized by the lack of both the A and B subunits; and type II
deficiency, characterized by the lack of the A subunit alone.
These defects can result in a lifelong bleeding tendency, defective
wound healing, and habitual abortion.
- 應用類型
- WB
- 免疫原
- P05160
- 來源宿主
- 反應性
- 保存建議
- 其他
- ABGENT
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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